{
  "schema_version": "0.1.0-research-proposals",
  "updated": "2026-10-28",
  "clinical_validation": false,
  "scored_new_cases": 0,
  "threshold_status": "not calibrated; report raw metrics and validity, not a composite leaderboard",
  "search_method": "Targeted search and primary-source verification using Ego Lite Browser; not systematic review",
  "sources": [
    {
      "id": "R1",
      "authors_short": "Sheng et al.",
      "year": 2025,
      "title": "Using Artificial Intelligence to Predict Implantable Collamer Lens Vault: A Low Parameter-Dependent Model for Better Surgical Outcomes",
      "doi": "10.1167/tvst.14.9.32",
      "url": "https://pubmed.ncbi.nlm.nih.gov/40985791/",
      "verification_level": "abstract"
    },
    {
      "id": "R2",
      "authors_short": "Yang et al.",
      "year": 2024,
      "title": "Clinical decision support system based on deep learning for evaluating implantable collamer lens size and vault after implantable collamer lens surgery: a retrospective study",
      "doi": "10.1136/bmjopen-2023-081050",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10875548/",
      "verification_level": "full_text_selected_sections"
    },
    {
      "id": "R3",
      "authors_short": "Li et al.",
      "year": 2026,
      "title": "EVO-ICL Vault Prediction: A Data Wrangling Framework Integrating Multicenter Big Data and Machine Learning",
      "doi": "10.1007/s40123-025-01288-8",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12882899/",
      "verification_level": "full_text_selected_sections"
    },
    {
      "id": "R4",
      "authors_short": "Yang, Fu, Heidrich",
      "year": 2024,
      "title": "Curriculum learning for ab initio deep learned refractive optics",
      "doi": "10.1038/s41467-024-50835-7",
      "url": "https://www.nature.com/articles/s41467-024-50835-7",
      "verification_level": "publisher_abstract_introduction_and_author_method_summary"
    },
    {
      "id": "R5",
      "authors_short": "Ntatsis et al.",
      "year": 2025,
      "title": "Deep learning ocular aberration retrieval from simulated retinal images under straylight",
      "doi": "10.1364/BOE.559749",
      "url": "https://pubmed.ncbi.nlm.nih.gov/40677828/",
      "verification_level": "abstract"
    },
    {
      "id": "R6",
      "authors_short": "Chen et al.",
      "year": 2019,
      "title": "Evaluation of Disk Halo Size after Implantation of a Collamer Lens with a Central Hole (ICL V4c)",
      "doi": "10.1155/2019/7174913",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6710753/",
      "verification_level": "full_text_measurements_and_results"
    }
  ],
  "cases": [
    {
      "id": "AI-01",
      "title": "跨中心拱高与不确定度",
      "track": "anatomy",
      "sources": [
        "R1",
        "R2",
        "R3"
      ],
      "status": "requires_authorized_clinical_dataset",
      "input": [
        "preoperative_biometry_with_units",
        "missingness_mask",
        "implanted_lens_identity",
        "followup_time"
      ],
      "output": [
        "vault_um",
        "prediction_interval_90_um",
        "missing_input_policy"
      ],
      "metrics": [
        "MAE_um",
        "RMSE_um",
        "interval_coverage",
        "interval_width_um",
        "per_center_errors"
      ],
      "split": "patient grouped, external center held out, preprocessing fitted on training only",
      "negative_controls": [
        "training_median",
        "no_uncertainty",
        "patient_eye_leakage_audit"
      ]
    },
    {
      "id": "AI-02",
      "title": "物理环境与隐藏干预",
      "track": "physics",
      "sources": [
        "R4"
      ],
      "status": "public_synthetic_development_examples_only",
      "input": [
        "explicit_synthetic_surfaces_and_media",
        "pupil",
        "source_angles_and_flux",
        "detector_and_units"
      ],
      "output": [
        "executable_solver",
        "path_resolved_linear_fields",
        "energy_ledger",
        "sampling_and_error_budget"
      ],
      "metrics": [
        "energy_relative_error",
        "fixed_coordinate_centroid_error_deg",
        "radial_energy_error",
        "intervention_difference_error",
        "invalid_rate"
      ],
      "split": "hidden parameter combinations and independent reference solver required",
      "negative_controls": [
        "fixed_ring_overlay",
        "exposure_changes_physical_values",
        "per_condition_retina_refocus"
      ],
      "public_examples": [
        "preop",
        "night",
        "small",
        "wide",
        "noport",
        "decenter"
      ]
    },
    {
      "id": "AI-03",
      "title": "受约束逆向推理与梯度",
      "track": "physics_inverse",
      "sources": [
        "R4"
      ],
      "status": "requires_gradient_validation_and_hidden_set",
      "input": [
        "multi_condition_linear_psfs",
        "known_geometry",
        "unknown_parameter_bounds"
      ],
      "output": [
        "candidate_parameters_with_units",
        "gradients",
        "forward_reprojection",
        "ambiguity_statement"
      ],
      "metrics": [
        "smooth_region_gradient_error_vs_independent_finite_difference",
        "heldout_forward_error",
        "geometry_invalid_rate",
        "identifiable_parameter_error"
      ],
      "split": "hold out observations and geometry families; exclude path discontinuities from smooth derivative claim",
      "negative_controls": [
        "surface_intersection",
        "unbounded_fit",
        "single_condition_overfit"
      ]
    },
    {
      "id": "AI-04",
      "title": "像差与杂散光辨析",
      "track": "physics_inverse",
      "sources": [
        "R5"
      ],
      "status": "requires_explicit_scatter_truth_generator",
      "input": [
        "linear_psf",
        "noise_model",
        "dynamic_range",
        "capture_method",
        "pupil_geometry"
      ],
      "output": [
        "wavefront_candidates",
        "scatter_candidates",
        "uncertainty",
        "forward_reprojection"
      ],
      "metrics": [
        "wavefront_RMS_without_piston",
        "forward_psf_residual",
        "OOD_error",
        "equivalent_solution_coverage"
      ],
      "split": "separate scatter model families and aberration ranges",
      "negative_controls": [
        "high_confidence_unique_cause_on_ambiguous_input",
        "symmetric_pupil_positive_negative_defocus_pair"
      ]
    },
    {
      "id": "AI-05",
      "title": "光学代理模型外推",
      "track": "physics_surrogate",
      "sources": [
        "R4"
      ],
      "status": "project_proposal_requires_hidden_geometry_and_reference",
      "input": [
        "training_geometry_parameters",
        "training_path_resolved_linear_fields",
        "hidden_test_parameters"
      ],
      "output": [
        "linear_field_prediction",
        "path_energy",
        "uncertainty",
        "training_cost_and_inference_time_and_hardware"
      ],
      "metrics": [
        "raw_power_error",
        "centroid_error_deg",
        "radial_energy_error",
        "conservation_error",
        "worst_group_error",
        "runtime"
      ],
      "split": "geometry family and parameter combination split; exposures of same field stay together",
      "negative_controls": [
        "nearest_neighbor",
        "analytic_fixed_ring",
        "tone_mapped_image_only"
      ]
    },
    {
      "id": "AI-06",
      "title": "测量语义与患者盲预测",
      "track": "perception",
      "sources": [
        "R6"
      ],
      "status": "synthetic_reports_only_requires_pilot_and_authorized_data",
      "input": [
        "allowed_eye_measurements",
        "illumination_and_geometry",
        "postoperative_time",
        "measurement_endpoint"
      ],
      "output": [
        "presence_probability",
        "halo_features_in_deg",
        "prediction_intervals",
        "endpoint_definition"
      ],
      "metrics": [
        "existing_patient_layer_subscores",
        "test_retest_noise",
        "patient_macro_score",
        "heldout_patient_error"
      ],
      "split": "patient grouped across eyes, conditions and visits; no target drawings provided to agent",
      "negative_controls": [
        "disk_halo_equals_bright_ring",
        "burden_equals_psf_energy",
        "always_one_fixed_ring"
      ]
    }
  ]
}
